Response Rates, Survival, and Chemotherapy Trials
نویسندگان
چکیده
منابع مشابه
Response rates, survival, and chemotherapy trials.
Early clinical trials of a novel oncology agent or combination regimen usually examine the biologic activity of the therapy using surrogate end points. These end points are believed to predict the clinical benefit of the new treatment, which is then tested in subsequent controlled, randomized clinical trials. The most commonly used surrogate end point, the response rate, has conventionally been...
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Background: Response rates such as overall response rate (ORR), complete response (CR) and complete response with incomplete blood recovery (CRi) can be evaluated in a much shorter period of time than overall survival (OS), potentially accelerating decision making during drug development. The objective of this work was to evaluate the relationship between ORR, CR, CRi or better (CRi+CR) rates a...
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BACKGROUND The activity of various chemotherapy regimens used in the treatment of advanced colorectal cancer is assessed by different groups of investigators and in various trials by what appear to be common criteria. However, there may be substantial inter-trial variation in the interpretation and application of these criteria which contributes to differences in response rates reported for the...
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ژورنال
عنوان ژورنال: Journal of the National Cancer Institute
سال: 2000
ISSN: 1460-2105
DOI: 10.1093/jnci/92.19.1552